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KMID : 1100220060050020063
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Dementia and Neurocognitive Disorders
2006 Volume.5 No. 2 p.63 ~ p.69
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Risk Factors and Neuropsychological Characteristics According to Subtypes of Subcortical Ischemic Vascular Dementia: Preliminary Study
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Ha Sang-Won
Ahn Hyun-Jung
Kwon Mi-Seon
Lee Jae-Hong
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Abstract
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Background: Subcortical ischemic vascular dementia (SIVD) results from small vessel disease, which produces either arteriolar occlusion (lacunar infarct) or a widespread incomplete infarct of the white matter (Binswanger’s disease). Little data have been available concerning the differentiation between the subtypes of SIVD.
Methods: Thirty-nine patients (22 males; mean age, 67 years) were included. All patients underwent the Seoul Neuropsychological Screening Battery and their medical records and brain MRIs were reviewed. Patients were divided into three groups by Erkinjuntti’s MRI criteria: lacunar type, white matter type, and mixed type. Vascular risk factors, neuropsychological findings, and the presence of depression were compared among those groups.
Results: Eleven patients were classified into the lacunar type group, 12 patients into the white matter type group, and 16 patients into the mixed type group. There was no statistical difference among the 3 groups in the demographic and vascular risk factor profiles except in the history of stroke or transient ischemic attack. The trend was noted that neuropsychological deficits were the most severe in the mixed type group and moderately severe in the white matter type group. The frequency of depression tended to be higher in the mixed group but there was no statistical significance.
Conclusions: Our study suggests that there may be some differences among the subtypes of SIVD in vascular risk factors, frontal/executive function, and associated depression, with a tendency of the mixed type to be the most affected and the white matter type to be the next. These findings need to be replicated further by a large clinical study.
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KEYWORD
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Subcortical ischemic vascular dementia, Vascular Risk factors, Depression, Neuropsychological test
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